Share your point of view on recently published study on Journal of Hypertension

"Hypertensive target organ damage and the risk for vascular events and all-cause mortality in patients with vascular disease" - Journal of Hypertension - March 2013

Dear RHC community

I would like to share with you this recently published study  « Hypertensive target organ damage and the risk for vascular events and all-cause mortality in patients with vascular disease » and to ask you to give your point of view on it.

The Second Manisfestation of Arterial Disease (SMART) study is an ongoing single-center (UTRECHT) prospective cohort study designed to establish the presence of additonal arterial disease and the risk factors for atherosclerosis in patients with manifest vascular diseases or a vascular risk factor.

The aim was to evaluate the prevalence of the separate and combined presence of impaired renal function, albuminuria, and LVH and to establish the risk of the separate and combined presence of these signs of hypertensive target organ damage on the vascular events and mortality in patients with clinically manifest vascular disease.

Hypertension was defined as an SBP of at least 140 mmHg and/or the use of blood pressure-lowering medication. The current study population includes 4,319 patients.

The combined presence of at least two manifestations of hypertensive target organ damage was found in 8% of patients.

Compared with non target organ damage, the single presence of target organ damage was associated with increased risk of established vascular endpoint.

I would like to share your opinion on the following:

  • Would the devices based therapy targeting the sympathic nervous system be better adapted for this high-risk population ?

During the day 2 of RHC Course, we discussed  the point of renal dysfunction as an inclusion or exclusion criteria  for Sympathetic renal denervation.  I would particularly appreciate hearing Roland Schmieder point of view on this.

Naturally, I am also keen to hear from the RHC community so please, share your thoughts here online!

Jean Marco

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